{"id":19247,"date":"2021-07-09T08:22:14","date_gmt":"2021-07-09T06:22:14","guid":{"rendered":"https:\/\/asscat-hepatitis.org\/?p=19247"},"modified":"2021-07-09T08:22:14","modified_gmt":"2021-07-09T06:22:14","slug":"identifiquen-un-nou-mecanisme-clau-en-el-desenvolupament-de-fetge-gras-no-alcoholic","status":"publish","type":"post","link":"https:\/\/asscat-hepatitis.org\/ca\/identifiquen-un-nou-mecanisme-clau-en-el-desenvolupament-de-fetge-gras-no-alcoholic\/","title":{"rendered":"Identifiquen un nou mecanisme clau en el desenvolupament de fetge gras no alcoh\u00f2lic"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;3.0.106&#8243; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;0px||0px|&#8221; next_background_color=&#8221;#000000&#8243;][et_pb_row custom_padding=&#8221;0px||0px|&#8221; _builder_version=&#8221;3.0.106&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_post_title author=&#8221;off&#8221; date_format=&#8221;d\/m\/Y&#8221; comments=&#8221;off&#8221; featured_placement=&#8221;background&#8221; text_background=&#8221;on&#8221; text_bg_color=&#8221;#ffffff&#8221; module_class=&#8221;ac-post-title-section-0&#8243; _builder_version=&#8221;3.0.106&#8243; title_font=&#8221;Montserrat|600|||||||&#8221; title_text_color=&#8221;#2d2d2d&#8221; title_letter_spacing=&#8221;-1px&#8221; title_line_height=&#8221;1.2em&#8221; meta_font=&#8221;Open Sans||||||||&#8221; meta_text_color=&#8221;rgba(45,45,45,0.5)&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|20px|20px|20px&#8221; title_text_align=&#8221;center&#8221; meta_font_size=&#8221;13px&#8221; meta_text_align=&#8221;center&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_post_title][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; _builder_version=&#8221;3.0.106&#8243; custom_padding=&#8221;||0px|&#8221; prev_background_color=&#8221;#000000&#8243; module_class=&#8221;ac-post-section-share-rrss&#8221; next_background_color=&#8221;#000000&#8243;][et_pb_row custom_padding=&#8221;||0px|&#8221; custom_margin=&#8221;|||&#8221; _builder_version=&#8221;3.0.105&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_divider color=&#8221;#e20611&#8243; show_divider=&#8221;on&#8221; divider_style=&#8221;ridge&#8221; _builder_version=&#8221;3.0.106&#8243; \/][et_pb_text _builder_version=&#8221;3.0.106&#8243; text_font=&#8221;Montserrat||||||||&#8221; text_text_color=&#8221;#e20611&#8243; text_orientation=&#8221;center&#8221; custom_margin=&#8221;||0px|&#8221; custom_padding=&#8221;|||&#8221; background_layout=&#8221;light&#8221; disabled=&#8221;on&#8221;]<\/p>\n<h5>Desde aqu\u00ed puedes compartir esta publicaci\u00f3n. \u00a1Gracias!<\/h5>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; specialty=&#8221;on&#8221; _builder_version=&#8221;3.0.106&#8243; custom_padding=&#8221;0px|||&#8221; prev_background_color=&#8221;#000000&#8243;][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243;][et_pb_row_inner admin_label=&#8221;Fila&#8221; _builder_version=&#8221;3.0.106&#8243;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Contenido Entrada 1&#8243; ul_type=&#8221;square&#8221; module_class=&#8221;ac-posts-content&#8221; _builder_version=&#8221;3.0.106&#8243; text_orientation=&#8221;justified&#8221; background_layout=&#8221;light&#8221; disabled=&#8221;on&#8221;]<\/p>\n<h3>Les alteracions en la nedilaci\u00f3 han mostrat estar implicades en algunes patologies hep\u00e0tiques com el c\u00e0ncer hep\u00e0tic, la fibrosi, la cirrosi i, ara, en el desenvolupament del fetge gras no alcoh\u00f2lic.<\/h3>\n<p>S\u2019ha comprovat, en models animals, que la inhibici\u00f3 farmacol\u00f2gica del proc\u00e9s de nedilaci\u00f3 provoca la reducci\u00f3 dels nivells de greix en el fetge gras, aix\u00ed com la inflamaci\u00f3 i el dany cel\u00b7lular. Els resultats de la investigaci\u00f3 han estat publicats a la revista <em>Molecular Metabolism<\/em>.<\/p>\n<p>La Dra. Teresa Cardoso Delgado\u00a0i la investigadora predoctoral, Marina Serrano, del grup liderat per la Dra. Mart\u00ednez-Chantar del CIC bioGUNE (membre del BRTA i pertanyent al Ciberehd), que compten amb el suport de l\u2019Associaci\u00f3 Espanyola Contra el C\u00e0ncer (AECC), han publicat recentment a la revista <em>Molecular Metabolism<\/em> un nou aven\u00e7 en l\u2019estudi del fetge gras no alcoh\u00f2lic, una condici\u00f3 pr\u00e8via al c\u00e0ncer hep\u00e0tic. En aquest treball es descriu la identificaci\u00f3 d\u2019un proc\u00e9s que pot ser clau per aturar a temps aquesta patologia cr\u00f2nica abans de la seva evoluci\u00f3 a c\u00e0ncer.<\/p>\n<p>En concret, el proc\u00e9s estudiat \u00e9s la nedilaci\u00f3, un mecanisme pel que certes mol\u00e8cules produ\u00efdes a les c\u00e8l\u00b7lules s\u00f3n modificades per complir diferents funcions i mantenir l\u2019equilibri. No obstant, algunes alteracions d\u2019aquest proc\u00e9s estan implicades en algunes patologies hep\u00e0tiques com el c\u00e0ncer hep\u00e0tic, la fibrosi, la cirrosi i, ara, en la malaltia del fetge gras no alcoh\u00f2lic.<\/p>\n<p>Usant tant mostres de pacients com models de laboratori, els investigadors del CIC bioGUNE Ciberehd, en col\u00b7laboraci\u00f3 amb altres grups d\u2019investigaci\u00f3 (Rub\u00e9n Nogueiras, Patricia Aspichueta Cela\u00e1, Jes\u00fas M. Banales, Mat\u00edas \u00c1vila, Jos\u00e9 Juan Garc\u00eda Mar\u00edn, Dimitris Xirodimas i cl\u00ednics nacionals i internacionals, com Javier Crespo de l\u2019Hospital Marqu\u00e9s de Valdecilla-IDIVAL, entre d\u2019altres), han observat que els nivells de mol\u00e8cules nedilades (\u00e9s a dir, mol\u00e8cules que han patit nedilaci\u00f3) estan considerablement elevats, el que vol dir que aquests nivells poden servir com un indicador d\u2019aquest problema hep\u00e0tic.<\/p>\n<p>A m\u00e9s d\u2019aix\u00f2, usant models animals, els investigadors han comprovat que la inhibici\u00f3 farmacol\u00f2gica del processos de nedilaci\u00f3 provoca la reducci\u00f3 dels nivells de greix al fetge, aix\u00ed com la inflamaci\u00f3 i el dany cel\u00b7lular, una estrat\u00e8gia que podria ser aplicable i ajudar a prevenir el c\u00e0ncer de fetge precedit pel fetge gras no alcoh\u00f2lic.<\/p>\n<p>&nbsp;<\/p>\n<p>Font: <a href=\"https:\/\/www.cicbiogune.es\/news\/identifican-un-nuevo-mecanismo-clave-en-el-desarrollo-de-h%C3%ADgado-graso-no-alcoh%C3%B3lico\">cicbiogune.es<\/a><\/p>\n<p>Refer\u00e8ncia: <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2212877821001204?via%3Dihub\">sciencedirect.com<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;Fila&#8221; custom_padding=&#8221;0px|||&#8221; _builder_version=&#8221;3.0.105&#8243; custom_margin=&#8221;|||&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_post_title admin_label=&#8221;Metadatos &#8211; Fecha \u00daltima actualizaci\u00f3n&#8221; title=&#8221;off&#8221; author=&#8221;off&#8221; date_format=&#8221;d\/m\/Y&#8221; categories=&#8221;off&#8221; comments=&#8221;off&#8221; featured_image=&#8221;off&#8221; _builder_version=&#8221;3.0.106&#8243; title_text_align=&#8221;left&#8221; meta_font=&#8221;Open Sans||||||||&#8221; meta_text_align=&#8221;left&#8221; meta_font_size=&#8221;13px&#8221; meta_text_color=&#8221;#0082ca&#8221; border_width_top=&#8221;1px&#8221; border_color_top=&#8221;#cccccc&#8221; custom_margin=&#8221;50px|||&#8221; custom_padding=&#8221;10px|||&#8221; custom_css_before=&#8221;content:%22\u00daltima actualizaci\u00f3n:%22;&#8221; global_module=&#8221;3449&#8243; saved_tabs=&#8221;all&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_post_title][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_sidebar orientation=&#8221;right&#8221; 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